Scholarly Work

Publications

Publications

38 peer-reviewed publications spanning DNA biomaterials, regenerative medicine, and biomineralization.

38 Publications

PI Karina Carneiro · Trainee lab member · † equal contributions

A At University of Toronto (2016–Present)

2026

Sci Reports
2026

Enhanced oral delivery and bioactivity of EGCG via DNA nanocarriers.

Chrisostomo, D. A.; Athanasiadou, D.; Eymael, D.; Sarma, T.; Duque, C.; Prakki, A.†; Carneiro, K.†

Scientific Reports 16, 21162, 2026

PNAS
2026

Crosslinking of collagen fibrils leads to preferential gap zone mineralization in vitro.

Gao, R.; Zhong, L.; DiCecco, L.; Wojtas, M.; Carneiro, K.; Grandfield, K.; Sone, E. D.

Proceedings of the National Academy of Sciences 123 (17), e2528176123, 2026

PNAS
2026

Identification and characterization of a wet adhesive protein extracted from Dreissena bugensis, the freshwater quagga mussel.

Obille, A.; Hasan, R.; Rees, D. J.; Ng, J.; Carneiro, K.; Sone, E. D.

Proceedings of the National Academy of Sciences 123 (11), e2537453123, 2026

2025

Adv Healthcare Mater
2025

Biomimetic Mineralization of Keratin Scaffolds for Enamel Regeneration.

Gamea, S.; Radvar, E.; Athanasiadou, D.; Lee Chan, R.; De Sero, G.; Ware, E.; Kundi, S.; Patel, A.; Horamee, S.; Hadadi, S.; Carlsen, M.; Allison, L.; Fleck, R.; Chan, K. L. A.; Banerjee, A.; Pugno, N.; Liebi, M.; Sharpe, P.; Carneiro, K.; Elsharkawy, S.

Advanced Healthcare Materials, e02465, 2025

Acta Biomaterialia
2025

DNA as a promising new biomaterial for bone regeneration.

Meshry, N.; Carneiro, K.

Acta Biomaterialia 197, 68, 2025

2024

J Funct Biomater
2024

Chemical and ultrastructural characterization of dentin treated with remineralizing toothpastes.

Athanasiadou, D.; Eymael, D.; Hajhamid, B.; Carneiro, K.; Prakki, A.

Journal of Functional Biomaterials 15 (1), 25, 2024

2023

PNAS
2023

DNA hydrogels for bone regeneration.

Athanasiadou, D.; Meshry, N.; Monteiro, N. G.; Ervolino-Silva, A.; Lee Chan, R.; McCulloch, C.; Okamoto, R.; Carneiro, K.

Proceedings of the National Academy of Sciences 120 (17), e2220565120, 2023

Highlighted in Extracellular Matrix News and PNAS showcase in Kudos.

Basic Transl Sci
2023

Focusing on the native matrix proteins in calcific aortic valve stenosis.

Anousakis-Vlachochristou, N.; Athanasiadou, D.; Carneiro, K.; Toutouzas, K.

JACC: Basic to Translational Science 8 (8), 1028, 2023

Dental Materials
2023

Effect of odanacatib on the release of NTX (amino terminal telopeptide) from LPS contaminated type I dentin collagen.

Bafail, A.; Carneiro, K.; Kishen, A.; Prakki, A.

Dental Materials 39 (2), 162, 2023

2022

Preprint
2022

Functionalized DNA tetrahedron for concomitant delivery of doxorubicin and paclitaxel.

Eymael, D.; Carneiro, K.†; Magalhaes, M.†

Preprint (Version 1) available at Research Square, 2022

Microsc Microanal
2022

Exploring calcium phosphate biomineralization systems using in situ liquid phase electron microscopy.

DiCecco, L.; Gao, R.; Athanasiadou, D.; Lee Chan, R.; Carneiro, K.; Kelly, D.; Sone, E.; Grandfield, K.

Microscopy and Microanalysis 28 (Suppl. 1), 1818, 2022

J Cell Physiology
2022

DDR1 associates with TRPV4 in matrix adhesions to enable calcium-regulated myosin activity and collagen compaction.

Wang, A.; Coelho, N.; Arora, P.; Eymael, D.; Ji, C.; Wang, Q.; Lee, W.; Kapus, A.; Carneiro, K.; McCulloch, C.

Journal of Cellular Physiology 237 (5), 2451, 2022

ACS Appl Mater Interfaces
2022

Peptide-decorated DNA nanostructures promote site-specific hydroxyapatite growth.

Danesi, A.; Athanasiadou, D.; Aderinto, A.; Rasie, P.; Chou, L.; Carneiro, K.

ACS Applied Materials & Interfaces 14 (1), 1692, 2022

2021

Int J Mol Sciences
2021

Amelotin promotes guided mineral growth on amelogenin nanoribbons.

Danesi, A.; Athanasiadou, D.; Mansouri, A.; Neshatian, M.; Holcroft, J.; Bonde, J.; Ganss, B.; Carneiro, K.

International Journal of Molecular Sciences 22 (22), 12343, 2021

J Dental Research
2021

A brief history of the discovery of amelogenin nanoribbons in vitro and in vivo.

Bai, Y.; Bonde, J.; Carneiro, K.; Zhang, Y.; Li, W.; Habelitz, S.

Journal of Dental Research 100 (13), 1429, 2021

Circulation
2021

Improved rabbit model of calcific aortic valve disease induces severe medial calcification and stenosis equivalent to human disease.

Anousakis-Vlachochristou, N.; Mavroidis, M.; Athanasiadou, D.; Varela, A.; Makridakis, M.; Katsa, M.; Miliou, A.; Lali, D.; Carneiro, K.; Vlahou, A.; Thomaidis, N.; Anagnostopoulos, C.; Cokkinos, D.; Tsioufis, C.; Toutouzas, K.

Circulation 144, A13262, 2021

ChemNanoMat
2021

Hydroxyapatite growth on amelogenin-amelotin recombinamers.

Athanasiadou, D.; Danesi, A.; Umbrio, L.; Holcroft, J.; Ganss, B.; Carneiro, K.

ChemNanoMat 7 (7), 851, 2021

Nature Rev Chem
2021

DNA nanostructures as templates for biomineralization.

Athanasiadou, D.; Carneiro, K.

Nature Reviews Chemistry 5, 93, 2021

Earlier

BBA Mol Cell Res
2020

Roles of PAK1 and filamin A in regulation of vimentin assembly and cell extension formation.

Ding, I.; Ostrowska-Podhorodecka, Z.; Lee, W.; Liu, R.; Carneiro, K.; Janmey, P.; McCulloch, C.

Biochimica et Biophysica Acta — Molecular Cell Research 1867 (9), 118739, 2020

Chemical Science
2019

Functionalized DNA nanostructures as scaffolds for guided mineralization.

Kim, F.; Chen, T.; Burgess, T.; Rasie, P.; Selinger, L.; Greschner, A.; Rizis, G.; Carneiro, K.

Chemical Science 10, 10537, 2019

PLoS One
2017

The role of protease inhibitors on the remineralization of demineralized dentin using the PILP method.

Nurrohman, H.; Carneiro, K.; Hellgeth, J.; Saeki, K.; Marshall, S.; Marshall, G.; Habelitz, S.

PLoS ONE 12 (11), e0188277, 2017

B Prior to joining University of Toronto (Prior to 2016)

Earlier

Sci Reports
2016

Amyloid-like ribbons of amelogenin in enamel mineralization.

Carneiro, K.; Zhai, H.; Li, Z.; Horst, J.; Sitlin, M.; Nguyen, M.; Wagner, M.; Simpliciano, C.; Milder, M.; Chen, C.-C.; Ashby, P.; Bonde, J.; Li, W.; Habelitz, S.

Scientific Reports 6, 23105, 2016

J Materials Research
2016

Repair of dentin defects from DSPP knockout mice by PILP mineralization.

Nurrohman, H.; Saeki, K.; Carneiro, K.; Chien, Y.; Qin, C.; Djomehri, S.; Ho, S.; Gower, L.; Marshall, S.; Marshall, G.; Habelitz, S.

Journal of Materials Research 31 (3), 321, 2016

Microsc Microanal
2015

New hybrid peak-force tapping/near-field microscope for nano-chemical and nano-mechanical imaging of graphene plasmons, polymers and proteins.

Wagner, M.; Andreev, G.; Carneiro, K.; Habelitz, S.; Muller, T.

Microscopy and Microanalysis 21 (S3), 1873, 2015

Nano Res & Appl
2015

Recent advances in self-assembled DNA nanosensors.

Carneiro, K.; Greschner, A.

American Journal of Nano Research and Application 3 (1), 1, 2015

JACS
2014

Precision polymer and 3D DNA nanostructures: emergent assemblies from new parameter space.

Serpell, C.; Edwardson, T.; Chidchob, P.; Carneiro, K.; Sleiman, H.

Journal of the American Chemical Society 136, 15767, 2014

Selected for a Research Spotlight in JACS.

Chemical Science
2014

Sequence-responsive unzipping DNA cubes with tunable cellular uptake profiles.

Bujold, K.; Fakhoury, J.; Edwardson, T.; Carneiro, K.; Briard, J.; Godin, A.; Amrein, L.; Hamblin, G.; Panasci, L.; Wiseman, P.; Sleiman, H.

Chemical Science 5, 2449, 2014

Highlighted in Chemistry World, 16-April-2014.

Angew Chem
2014

An efficient and modular route to sequence-defined polymers appended to DNA.

Edwardson, T.; Carneiro, K.; Serpell, C.; Sleiman, H.

Angewandte Chemie International Edition 53, 4567, 2014

Selected as a ‘Very Important Paper’ and for cover page.

WIREs Nanomed
2013

Long-range self-assembly of nucleic acids into fibers and highly ordered networks.

Carneiro, K.; Avakyan, N.; Sleiman, H.

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2013

Nature Chemistry
2013

Site-specific positioning of dendritic alkyl chains on DNA cages enables their geometry-dependent self-assembly.

Edwardson, T.; Carneiro, K.; McLaughlin, C.; Serpell, C.; Sleiman, H.

Nature Chemistry 5, 868, 2013

Selected for CSACS Best Paper award; ranked number 8 in Nature Chemistry’s top 10 research papers for 2013; highlighted in several news articles.

ACS Nano
2013

A simple design for DNA nanotubes from a minimal set of unmodified strands: rapid, room temperature assembly and readily tunable structure.

Hamblin, G.; Hariri, A.; Carneiro, K.; Lau, K.; Cosa, G.; Sleiman, H.

ACS Nano 7, 3022, 2013

Chemical Science
2012

Stimuli-responsive organization of block copolymers on DNA nanotubes.

Carneiro, K.; Hamblin, G.; Hänni, K.; Fakhoury, J.; Nayak, M.; Rizis, G.; McLaughlin, C.; Bazzi, H.; Sleiman, H.

Chemical Science 3, 1980, 2012

JACS
2012

Rolling circle amplification-templated DNA nanotubes show increased stability and cell penetration ability.

Hamblin, G.; Carneiro, K.; Fakhoury, J.; Bujold, K.; Sleiman, H.

Journal of the American Chemical Society 134, 2888, 2012

JACS
2012

Three-dimensional organization of block copolymers on “DNA-minimal” scaffolds.

McLaughlin, C.; Hamblin, G.; Hänni, K.; Conway, J.; Nayak, M.; Carneiro, K.; Bazzi, H.; Sleiman, H.

Journal of the American Chemical Society 134, 4280, 2012

Book Chapter
2011

Self-assembly of nucleic acids.

Carneiro, K.; Lo, P.; Sleiman, H.

Supramolecular Chemistry: From Molecules to Nanomaterials, Eds. Steed, J. W.; Gale, P. A., John Wiley & Sons, 2011

Tetrahedron Lett
2011

The first example of trimethylsilyl methylenenitronate reacting with aldehydes under an apparent Mukaiyama nitro-aldol reaction.

MacDonald, F.; Carneiro, K.; Pottie, I.

Tetrahedron Letters 52, 891, 2011

JACS
2010

Long-range assembly of DNA into rigid nanofibers and highly ordered networks using a block copolymer approach.

Carneiro, K.; Aldaye, F.; Sleiman, H.

Journal of the American Chemical Society 132, 679, 2010

Selected as ‘Editor’s Choice’ in Science, 12-February-2010.

Bioorg Med Chem
2006

On the active site for hydrolysis of aryl amides and choline esters by human cholinesterases.

Darvesh, S.; McDonald, R.; Darvesh, K.; Mataija, D.; Monthana, S.; Cook, H.; Carneiro, K.; Richard, N.; Walsh, R.; Martin, E.

Bioorganic & Medicinal Chemistry 14, 4586, 2006

01

Selected Presentations

At University of Toronto (2016–Present) — invited talks, keynotes, and conference presentations spanning DNA biomaterials and mineralized tissue regeneration.

June 2026 Invited speaker

“DNA Hydrogel Biomaterials for Mineralized Tissue Regeneration”

2026 CBS/CSPS/CC-CRS Conference  ·  Vancouver, BC, Canada

May 2026 Invited speaker

“DNA Hydrogel Biomaterials for Critical-Size Bone Defect Regeneration”

Canadian Societies for Chemistry and Chemical Engineering 2026  ·  Toronto, ON, Canada

June 2024 Invited keynote

“DNA: From self-assembly to mineralized tissue regeneration”

Young Investigators – Fresh Voices, Fresh Ideas, Canadian Society for Pharmaceutical Sciences  ·  Edmonton, AB, Canada

February 2024 Invited role model

“Meet our Mentors: learn about their career paths, their stories, their experiences…”

NSERC PROMOTE Networking, Promote women in science  ·  Virtual

August 2023 Invited lecturer

“DNA nanotechnology”, “Biopolymers for biomineralization”, “DNA nanostructures as scaffolds for bone repair”

Universidade Estadual Paulista “Julio de Mesquita Filho” Campus de Araçatuba  ·  Special Topics Course (graduate)

June 2023 Invited oral

“The promise of DNA-based materials”

Annual New Member Induction Evening, Omicron Kappa Upsilon National Dental Honor Society  ·  University of Toronto

April 2023 Invited oral

“DNA hydrogels for bone regeneration”

Symposium Day, Biomaterials and Biofabrication for Regenerative Medicine Applications  ·  McMaster University

February 2023 Invited oral

“Biopolymers: From self-assembly to mineralized tissue regeneration”

Research day, Faculty of Dentistry  ·  University of Toronto

June 2022 Invited oral

“DNA hydrogels for bone regeneration”

Leeds Dental School Online Research Seminar Series

August 2021 Invited oral

“Peptide-decorated DNA nanostructures promote site-specific hydroxyapatite growth”

IUPAC | CCCE 2021, 48th World Chemistry Congress and 104th Canadian Chemistry Conference and Exhibition  ·  Montreal, QC, Canada

June 2019 Oral · Session organizer

“DNA nanostructures as scaffolds for mineralization”

AADR/IADR/CADR General Session and Exhibition  ·  Vancouver, BC, Canada

November 2018 Poster

“Enamel proteins for guided mineral growth”

MRS Fall Meeting and Exhibit  ·  Boston, MA, USA

March 2017 Oral · Session organizer

“Self-assembled amelogenin and DNA as guides for apatite”

AADR/IADR/CADR General Session and Exhibition  ·  San Francisco, CA, USA

November 2016 Oral & poster · ECR Award

“Polymer induced liquid precursor (PILP) method applied to amelogenin nanoribbons”

Enamel 9 Meeting  ·  Leeds, United Kingdom

September 2016 Invited oral

“DNA nanostructures as templates for mineralization”

Matrix Dynamics Group, University of Toronto  ·  Toronto, ON, Canada

August 2016 Poster

“In vitro self-assembly and mineralization of enamel matrix protein”

Gordon Research Conference (Biomineralization)  ·  Girona, Spain

02

Invention Disclosures

PI Karina Carneiro · Trainee lab member · † equal contributions

A At University of Toronto (2016–Present)

November 2019 Invention Disclosure

“Functionalized DNA nanostructure for targeted chemotherapy multidrug delivery”

Eymael, D.; †Magalhaes, M.; †Carneiro, K.

Disclosure No. 10003898

September 2019 Invention Disclosure

“Novel resin with remineralizing capacity”

†Burgess, T.; †Prakki, A.; †Carneiro, K.

Disclosure No. 10003855

B Prior to joining University of Toronto (Prior to 2016)

November 2016 Report of Invention

“Amelogenin peptides for restoring and repairing mineral tissues”

Li, W.; Habelitz, S.; Zhai, H.; Zhu, L.; Carneiro, K.; Zhan, L.; Ho, S.; DenBesten, P.

January 2014 Report of Invention

“Sequence-Controlled and Monodisperse Polymers Conjugated to DNA”

Edwardson, T.; Carneiro, K.; Serpell, C.; Sleiman, H.

US Provisional Patent Application, December 2014, 61/940,657

US Patent Application US20150231254A1 →
August 2008 Provisional Patent Application

“Dendritic DNA supermolecules”

Carneiro, K.; Aldaye, F.; Sleiman, H.